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KMID : 0369820070370040243
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 4 p.243 ~ p.247
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Study on the Influence of Cubic Liquid Crystalline Phases of Monoolein on the Stability and Transdermal Delivery of Retinylpalmitate
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Lee Kyoung-Gum
Lee Jae-Hwi
Choi Young-Wook
Kang Myung-Joo
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Abstract
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Retinoids have many important and diverse functions and particularly, have been widely used as anti-aging agent and for the treatment of acne and psoriasis in cosmetics. However, retinoids have low stability against the air, light, water, oxygen and heat, thus, to stabilize the retinoids in formulations is very critical procedure. In this study, cubic liquid crystalline phase of monoolein was applied to stabilize the retinylpalmitate (RP) and to enhance the transdermal permeation. Cubic liquid crystalline phase significantly enhanced the stability of RP. After 15 days, the content of RP in the cubic formulation was 94.7% while the content of RP in ethanol solution was below 0.5% at room temperature. Although BHT containing crystalline phase showed the slightly increased stability of RP, there were no significant differences in RP stability between with or without antioxidants (ascorbic acid, -tocopherol, BHT, BHA) at . The skin retention of RP in crystalline formulations was approximately times greater than that of o/w cream formulation. Incorporation of RP into cubic liquid crystalline phase of monoolein effectively stabilized the RP and worked as excellent topical vehicle for RP. Liquid crystalline phase is considered to be suitable formulation for RP for topical delivery system as a stabilizer and permeation enhancing agent.
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KEYWORD
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Retinoids, Monoolein, Liquid crystalline phase, Transdermal delivery, Stability, Antioxidants
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